A Single-cell Perturbation Landscape of Colonic Stem Cell Polarisation
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA883610
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资源简介：
Cancer cells are mutually regulated by both oncogenic mutations and stromal cues, yet these processes are often studied separately. To explore how cell-extrinsic and cell-intrinsic cues co-regulate cell-fate, we generated scRNA-seq data of murine colonic organoids regulated by 1) colorectal cancer (CRC) oncogenic mutations, 2) microenvironmental fibroblasts and/or macrophages, and/or 3) defined stromal signalling cues.
创建时间：
2022-09-23
