CLINICALANDPATHOGENETICASSESSMENTOFTHEIMPACTOFMETABOLICSYNDROMEONTHECOURSEOFRHEUMATOIDARTHRITIS
收藏Zenodo2026-01-22 更新2026-05-26 收录
下载链接：
https://zenodo.org/doi/10.5281/zenodo.18341274
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资源简介：
Rheumatoidarthritisisachronicsystemicinflammatorydiseasefrequentlyaccompaniedbymetabolicdisturbancesthatsignificantlyinfluencediseaseprogressionandlong-termoutcomes.Metabolicsyndrome,characterizedbyinsulinresistance,dyslipidemia,abdominalobesity,andarterialhypertension,hasbeenincreasinglyrecognizedasanimportantcomorbidityinpatientswithrheumatoidarthritis.Thisstudyaimstoassesstheclinicalandpathogeneticimpactofmetabolicsyndromeonthecourseofrheumatoidarthritis.Theanalysisshowsthatmetabolicsyndromeishighlyprevalentamongpatientswithrheumatoidarthritisandisassociatedwithincreasedinflammatoryactivity,moresevereclinicalmanifestations,andahigherriskofcardiovascularandskeletalcomplications.Chronicsystemicinflammationmediatedbypro-inflammatorycytokinesrepresentsakeymechanismlinkingjointdamagewithmetabolicabnormalities.Insulinresistanceandadipokineimbalancefurtherintensifyinflammatorypathways,creatingabidirectionalinteractionthatacceleratesdiseaseprogression.Thesefindingsunderlinetheimportanceofearlyidentificationandcomprehensivemanagementofmetabolicsyndromeinpatientswithrheumatoidarthritistoimprovediseasecontrolandreducecomorbidity-relatedmorbidity.
提供机构：
Zenodo
创建时间：
2026-01-22
