Supporting data for “Coronaviruses exploit a host cysteine-aspartic protease for replication”

Highly pathogenic coronaviruses including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Middle East respiratory syndrome coronavirus (MERS-CoV) and SARS-CoV-1 vary in their transmissibility and pathogenicity with underlying mechanism remains largely unexplained. However, substantial apoptosis induced by infection of all three viruses have been documented in infected cells and patient tissues, suggesting a previously unrecognized link between apoptosis cascade and the pathogenesis of coronaviruses. In this study, I show that a cysteine-aspartic protease which is the central component involved in apoptosis cascade, caspase-6, serves as an important host factor for efficient coronavirus replication.

All the data can be found in the preprint "Yuen K Y, Chu H, Hou Y, et al. Coronaviruses exploit a host cysteine-aspartic protease for efficient replication[J]. 2021.".

高度致病性冠状病毒，包括严重急性呼吸综合征冠状病毒2（SARS-CoV-2）、中东呼吸综合征冠状病毒（MERS-CoV）及SARS-CoV-1，其在传染性和致病性方面存在差异，其潜在机制尚普遍未解。然而，关于这三种病毒感染所致的细胞和患者组织中的显著细胞凋亡现象已有记录，这暗示了细胞凋亡级联反应与冠状病毒致病机制之间一个先前未被认知的关联。在本研究中，我揭示了作为细胞凋亡级联反应核心成分的半胱氨酸天冬氨酸蛋白酶，即caspase-6，充当了冠状病毒高效复制的重要宿主因子。所有数据均可在预印本“Yuen K Y, Chu H, Hou Y, et al. Coronaviruses exploit a host cysteine-aspartic protease for efficient replication[J]. 2021.”中找到。