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A Single-cell Perturbation Landscape of Colonic Stem Cell Polarisation|结直肠癌研究数据集|单细胞分析数据集
收藏Mendeley Data2024-05-10 更新2024-06-28 收录
下载链接：
https://zenodo.org/records/8167657
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链接失效反馈资源简介：
Cancer cells are regulated by oncogenic mutations and microenvironmental signals, yet these processes are often studied separately. To functionally map how cell-intrinsic and cell-extrinsic cues co-regulate cell-fate in colorectal cancer (CRC), we performed a systematic single-cell analysis of 1,107 colonic organoid cultures regulated by 1) CRC oncogenic mutations, 2) microenvironmental fibroblasts and macrophages, 3) stromal ligands, and 4) signalling inhibitors. Multiplexed single-cell analysis revealed a stepwise epithelial differentiation landscape dictated by combinations of oncogenes and stromal ligands, spanning from fibroblast-induced Clusterin (CLU)+ revival colonic stem cells (revCSC) to oncogene-driven LRIG1+ hyper-proliferative CSC (proCSC). The transition from revCSC to proCSC is regulated by decreasing WNT3A and TGF-β-driven YAP signalling and increasing KRASG12D or stromal EGF/Epiregulin-activated MAPK/PI3K flux. We find APC-loss and KRASG12D collaboratively limit access to revCSC and disrupt stromal-epithelial communication -- trapping epithelia in the proCSC fate. These results reveal that oncogenic mutations dominate homeostatic differentiation by obstructing cell-extrinsic regulation of cell-fate plasticity.
创建时间：
2023-07-27
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lmarena-ai/PPE-MATH-Best-of-K
--- dataset_info: features: - name: question_id dtype: string - name: problem dtype: string - name: level dtype: string - name: type dtype: string - name: solution dtype: string - name: sanitized_solution dtype: string - name: model_name dtype: string - name: prompt dtype: string - name: scores sequence: bool - name: parsed_outputs sequence: string - name: mean_score dtype: float64 - name: response_1 dtype: string - name: response_2 dtype: string - name: response_3 dtype: string - name: response_4 dtype: string - name: response_5 dtype: string - name: response_6 dtype: string - name: response_7 dtype: string - name: response_8 dtype: string - name: response_9 dtype: string - name: response_10 dtype: string - name: response_11 dtype: string - name: response_12 dtype: string - name: response_13 dtype: string - name: response_14 dtype: string - name: response_15 dtype: string - name: response_16 dtype: string - name: response_17 dtype: string - name: response_18 dtype: string - name: response_19 dtype: string - name: response_20 dtype: string - name: response_21 dtype: string - name: response_22 dtype: string - name: response_23 dtype: string - name: response_24 dtype: string - name: response_25 dtype: string - name: response_26 dtype: string - name: response_27 dtype: string - name: response_28 dtype: string - name: response_29 dtype: string - name: response_30 dtype: string - name: response_31 dtype: string - name: response_32 dtype: string - name: conflict_pairs sequence: sequence: int64 - name: sampled_conflict_pairs sequence: sequence: int64 splits: - name: train num_bytes: 28121544 num_examples: 512 download_size: 12452688 dataset_size: 28121544 configs: - config_name: default data_files: - split: train path: data/train-* --- # Overview This contains the MATH correctness preference evaluation set for Preference Proxy Evaluations. The prompts are sampled from [MATH](https://huggingface.co/datasets/hendrycks/competition_math). This dataset is meant for benchmarking and evaluation, not for training. [Paper](https://arxiv.org/abs/2410.14872) [Code](https://github.com/lmarena/PPE) # License User prompts are licensed under MIT, and model outputs are governed by the terms of use set by the respective model providers. # Citation ``` @misc{frick2024evaluaterewardmodelsrlhf, title={How to Evaluate Reward Models for RLHF}, author={Evan Frick and Tianle Li and Connor Chen and Wei-Lin Chiang and Anastasios N. Angelopoulos and Jiantao Jiao and Banghua Zhu and Joseph E. Gonzalez and Ion Stoica}, year={2024}, eprint={2410.14872}, archivePrefix={arXiv}, primaryClass={cs.LG}, url={https://arxiv.org/abs/2410.14872}, } ```
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