Enrichment of CVS tissue-specific exons for canonical splice sites.

For each pairwise comparison between CVS tissues, (column A, B: iPSC-CVPC vs. adult heart, iPSC-CVPC vs. adult arteria and adult heart vs. adult arteria), the table shows the differences in the probability of each base pair occurring in the 100 bp upstream of the splice acceptor site and the 100 bp downstream of the splice donor site. The table shows: the two tested CVS tissues (columns A, B); which splice site is tested (donor or acceptor, column C); the tested nucleotide (column D); the position relative to the exon start (negative values, upstream of the splice acceptor site) or end (positive values, downstream of the splice donor site) (column E); and the results obtained from Fisher’s exact test (fisher.test function in R), including the estimate (odds ratio, column F), its 95% confidence interval (column G, H) and the p-value (column I). In Fig 3C–3I, only the tests associated with the most common nucleotide at each position are shown. Fig 3D, 3F and 3H shows the estimate from Fisher’s exact test and its 95% confidence interval; whereas Fig 3E, 3G and 3I shows the p-values calculated with Fisher’s exact test.
(CSV)