Data from: Implementation of complex biological logic circuits using spatially distributed multicellular consortia

Engineered synthetic biological devices have been designed to perform a
variety of functions from sensing molecules and bioremediation to energy
production and biomedicine. Notwithstanding, a major limitation of in vivo
circuit implementation is the constraint associated to the use of standard
methodologies for circuit design. Thus, future success of these devices
depends on obtaining circuits with scalable complexity and reusable parts.
Here we show how to build complex computational devices using
multicellular consortia and space as key computational elements. This
spatial modular design grants scalability since its general architecture
is independent of the circuit’s complexity, minimizes wiring requirements
and allows component reusability with minimal genetic engineering. The
potential use of this approach is demonstrated by implementation of
complex logical functions with up to six inputs, thus demonstrating the
scalability and flexibility of this method. The potential implications of
our results are outlined.