Crystal structure of TRIM25 PRYSPRY covalently bound to 2-chloro-1-[4-(3-methyl-4-phenyl-phenyl)carbonyl-1,4-diazepan-1-yl]ethanone

Crystal structure of TRIM25 PRYSPRY covalently bound to 2-chloro-1-[4-(3-methyl-4-phenyl-phenyl)carbonyl-1,4-diazepan-1-yl]ethanone Descriptor: 1-[4-(3-methyl-4-phenyl-phenyl)carbonyl-1,4-diazepan-1-yl]ethanone, E3 ubiquitin/ISG15 ligase TRIM25 Authors: McPhie, K.A, Esposito, D, Rittinger, K. Deposit date: 2025-01-15 Release date: 2025-05-21 Last modified: 2025-06-25 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Discovery and optimisation of a covalent ligand for TRIM25 and its application to targeted protein ubiquitination. Chem Sci, 16, 2025