Palladium-Catalyzed C–N Bond Cleavage of 2<i>H</i>‑Azirines for the Synthesis of Functionalized α‑Amido Ketones
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A Pd-catalyzed ring-opening reaction of 2H-azirines with carboxylic acids was developed. This reaction undergoes nucleophilic addition between 2,3-diaryl-2H-azirines and carboxylic acids followed by C–N single-bond cleavage and a subsequent thermal rearrangement. This method enables the rapid construction of valuable α-amido ketone derivatives with high atomic efficiency and superb functional group tolerance.
创建时间：
2019-02-01
