The numerical data used in this study.

BackgroundSerological surveys of mumps are important for estimating susceptibility in the population and for evaluating the effectiveness of current vaccination strategies.MethodsA cross-sectional serological survey using an enzyme-linked immunosorbent assay was conducted on 5,147 participants in Guangdong, China, to evaluate the immunological effects of 2 doses of measles-mumps-rubella vaccine. In accordance with the instructions of the ELISA kit, the final readings represent the anti-mumps antibody titers, which are expressed in “NovaTec units”.ResultsOf the 5,147 participants, 3,888 were positive for mumps IgG antibodies, with a seroprevalence of 75.54% (95% CI: 74.34%-76.71%). For each age group, the mumps IgG seroprevalence rates were 74.40%, 89.02%, 85.58%, 68.60%, 69.28%, 78.42%, and 80.63% for those =60 years, respectively. In terms of the percentage decreases in anti-mumps antibody titers, in the population receiving the 1-dose vaccine, there was a mean decrease of 2.06% per year. In the population receiving 2 doses of the vaccine, the mean annual decreases were 10.33% and reached protective thresholds of approximately 12.3 years.ConclusionThe high mumps seroprevalence in the unvaccinated population revealed neglected hidden mumps infections. A time-lapse assay of IgG antibodies indicated that the mumps vaccine provided protection for one decade, which highlights that booster vaccinations may be needed in adults.