PD-1 governs the innate-adaptive immune interface in tuberculosis: insights from single-cell and spatial transcriptomics
收藏Zenodo2025-08-24 更新2026-05-26 收录
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https://zenodo.org/doi/10.5281/zenodo.16936169
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To investigate the role of PD-1 signaling in TB pathogenesis, we employed a well-established murine model of acute M.tb infection, wherein BALB/c mice were intravenously infected with a high dose of the attenuated M.tb strain H37Ra. To dissect the impact of PD-1 perturbation on immune cell dynamics, we employed a novel spatial transcriptomic platform to map the pulmonary immune landscapes at day 7 and day 28 post Mycobacterium tuberculosis (M.tb) infection in response to different treatment regimens.
The treatment regimens of PD-1 ablation are shown as follows:
1week infection: 1) WT mice + 7 days M.tb infection; 2) PD-1 gene knock out mice + 7 days M.tb infection; 3) WT mice + 7 days anti PD-1 antibody + 7 days M.tb infection
4 weeks infection: 1) WT mice + 28 days M.tb infection; 2) PD-1 gene knock out mice + 28 days M.tb infection; 3) WT mice + 28 days anti PD-1 antibody + 28 days M.tb infection; 4) WT mice + 7 days anti PD-1 antibody (21-28 days post infection) + 28 days M.tb infection
Our datasets including images, spatial gene matrix and spatial gene location.
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Zenodo
创建时间：
2025-08-24
