Clinical data of patients enrolled in the study.

F = female; LP = lumbar puncture time; EDSS = Expanded Disability Status Scale; ΔEDSS = difference between EDSS assessment at the diagnosis after 5 years of follow-up; fu = follow-up; RR = relapse-rate; DMT = disease-modifying treatments, indicated as: first line (I), second line (II) pharmacological treatments or absence of therapy (none). Clinical class. = clinical classification according: H (high) = highly aggressive disease, second-line therapy; M (moderate) = moderately aggressive disease, first-line therapy; L (low) = mildly aggressive disease; L (B) = “benign” disease, characterized by absence or progression no therapy. PPMS = primary progress multiple sclerosis; RRMS = relapsing remitting multiple sclerosis* data available at 2-year follow-up** data available at 1-year follow-up*** no therapy prescribed at diagnosis.Clinical data of patients enrolled in the study.