Impact of chorioamnionitis exposure on neonatal monocyte H3K4me3 patterning. Impact of chorioamnionitis exposure on neonatal monocyte H3K4me3 patterning

We sought to determine the impact of chorioamnionitis exposure on the neonatal monocyte H3K4me3 histone modification landscape over the course of fetal and neonatal immune system development using ChIP-seq. H3K4me3 ChIP-seq was performed on umbilical cord blood purified CD14+ monocytes from healthy and chorioamnionitis-exposed extremely preterm neonates (under 30 weeks gestation), late preterm neonates (30-36 weeks gestation), and term neonates (37+ weeks gestation). Overall design: H3K4me3 ChIP-seq on 9 samples with 3 replicates per age group (each replicate contains 3 pooled samples)