RNA-Seq of HCAEC treated with siRNA against scrambled or VKORC1 or VKORC1L1

This study investigates transcriptomic changes in human coronary artery endothelial cells (HCAEC) following siRNA-mediated gene silencing. Cells were transfected with either scrambled control siRNA or siRNA targeting VKORC1 or VKORC1L1. Total RNA was extracted and subjected to bulk RNA sequencing to assess differential gene expression profiles associated with loss of VKORC1 or VKORC1L1 function. The dataset enables analysis of gene expression changes related to vitamin K metabolism and downstream signaling pathways in endothelial cells.