Effects of Combined Treatment with Low-dosage ARNI and SGLT2i from Transcriptome Profiles of Murine Heart Tissue

To obtain the mechanical insights of heart in response to ARNI and SGLT2i combination treatment in chronic doxorubicin-injected mice. For chronic heart failure model, serial intraperitoneal injections of doxorubicin (2.5 mg/kg) or 0.9% sterile saline were administered every 4 days for 24 days (cumulative dosage, 15 mg/kg). One day after doxorubicin injection, the control mice were gavaged daily with vehicle (corn oil), while the experimental mice were gavaged daily with ARNI (68 mg/kg/day), SGLT2 inhibitor (1 mg/kg/day), Low-ARNI/SGLT2i (34 mg/kg/day) for 6 weeks. Overall design: The provided data comprise bulk RNA-sequencing data from mice treated with saline control (n=5), doxorubicin+vehicle (n=4), doxorubicin+ARNI (n=4), doxorubicin+SGLT2i (n=4), doxorubicin+Low-ARNI/SGLT2i (n=5).