Gut microbiota remodeling extends the health-span of aging mice

The world's elderly population has increased dramatically in recent years. Therefore, it is urgent to quest effective interventions that can slow down the process of ageing and extend the health-span of human. The available evidence suggested that gut dysbiosis may affect the rate of ageing, that is microbiological ageing, highlighting that the key to prolongation of health-span lies in the introduction of useful microbiota. Although previous study reported that potential probiotic supplementation improves a wide range of ageing-related phenotypes of old mice, the underlying mechanisms remains unclear.