CCL22

This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. [provided by RefSeq, Sep 2014]

本抗菌基因是位于第16号染色体q臂上的一组多个Cys-Cys（CC）细胞因子基因之一。细胞因子是一类分泌蛋白，参与免疫调节和炎症过程。CC细胞因子是一类以相邻的两个半胱氨酸为特征的蛋白质。由本基因编码的细胞因子对单核细胞、树突状细胞、自然杀伤细胞以及慢性激活的T淋巴细胞表现出趋化活性。此外，它对初级激活的T淋巴细胞具有一定的活性，但对中性粒细胞、嗜酸性粒细胞和静息T淋巴细胞没有趋化活性。本基因产物与趋化因子受体CCR4结合。这种趋化因子可能在激活的T淋巴细胞向炎症部位迁移及其他激活的T淋巴细胞生理学方面发挥作用。[由RefSeq提供，2014年9月]