Asymmetric Hydroboration Approach to the Scalable Synthesis of ((1R,3S)‑1-Amino-3-((R)‑6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)­cyclopentyl)­methanol (BMS-986104) as a Potent S1P1 Receptor Modulator

We describe a highly efficient route for the synthesis of 4a (BMS-986104). A key step in the synthesis is the asymmetric hydroboration of trisubstituted alkene 6. Particularly given the known difficulties involved in this type of transformation (6 → 7), the current methodology provides an efficient approach to prepare this class of compounds. In addition, we disclose the efficacy of 4a in a mouse EAE model, which is comparable to 4c (FTY720). Mechanistically, 4a exhibited excellent remyelinating effects on lysophosphatidyl­choline (LPC) induced demyelination in a three-dimensional brain cell culture assay.