Comparison of IC50 values for inhibition of OCT2-dependent uptake of metformin and maximum therapeutic plasma concentrations in humans.
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Cmax, maximum steady-state plasma concentration; Cmax,u, Cmax of unbound drug; IC50, experimentally determined concentration for half maximal inhibition of OCT2-mediated metformin (1000 μM) uptake. Cmax values were obtained from Regenthal et al. [16].Comparison of IC50 values for inhibition of OCT2-dependent uptake of metformin and maximum therapeutic plasma concentrations in humans.
创建时间：
2015-12-03
