Ursodeoxycholic Acid (UDCA) in Preventing Hepatobiliary and Colorectal Malignancy in Surveillance Patients with Primary Sclerosing Cholangitis (PSC)

Primary objectives: (i) To assess in incidence of biliary malignancy as assessed by surveillance MR/MRCP in patients with PSC with and without response to UDCA(ii) To assess in incidence of colorectal malignancy as assessed by surveillance colonoscopy in patients with PSC with and without response to UDCA
Primary endpoints: - any hepatobiliary malignancy including low-grade dysplasia detected by surveillance MRCP- any colorectal malignancy including low-grade dysplasia detected by surveillance colonoscopy