Raw data from photostability testing of agomelatine (AGM)-loaded microneedle systems

Raw data from stability testing of agomelatine (AGM)-loaded microneedle systems.Photostability test:To confirm the photostability of the best optimized formulations, the accelerated stability testing study was performed according to the ICH guidelines, under the following storage conditions: T=40±2°C and RH=75±5%. The test was conducted on with the use of TH-ICH-800 (Lab Companion, Republic of Korea) stability chamber.Quantification of AGM:The amount of AGM permeated was analyzed using High-Performance Liquid Chromatography (HPLC) (Shimadzu Nexera-I LC-2040C, Japan) with LabSolution Lite software.Chromatographic Conditions:Column: Reversed-phase C18 (HyperClone BDS C18, 5 µm, 4.6 × 250 mm, Phenomenex, Torrance, CA, USA)Column Temperature: 30.0 ± 0.2°CMobile Phase: Acetonitrile and 0.05 M potassium dihydrogen phosphate solution (pH = 2.9, adjusted with 85% orthophosphoric acid) in a 35:65 ratioMode: IsocraticFlow Rate: 1.0 mL/minDetection Wavelength: 230 nmThe set contains data in LCD format, created using the LabSolutions software (HPLC, Nexera LC 2040C). Data file (.lcd) contains all analysis results and acquisition information from the following files.