Glucosylation of Rab1 by a bacterial effector
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https://escience.org.cn/metadata/detail?cstrId=CSTR:17970.11.A001G.202003.000616&id=774e74221ac511e980780242ac120006:CSTR:A0006.11.A001G.202003.000616
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资源简介：
Posttranslationally modifying key host proteins by virulence factors is an important theme in bacterial pathogenesis. A remarkable example is the reversible modifications of the small GTPase Rab1 by multiple Legionella pneumophila effectors. Previous studies have shown that the effector SetA, dependent on a functional glucosyltransferase domain, interferes with host secretory pathways. However, the enzymatic substrate(s) of SetA in host cells remains unknown. Here, by using cross-linking mass spectrometry we uncovered Rab1 as the target of SetA during L. pneumophila infection
提供机构：
国家人口健康科学数据中心
创建时间：
2020-11-24
