Crystal Structure of BACE with Compound 12a
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Crystal Structure of BACE with Compound 12a Descriptor: (5R,7S)-1-(3-fluorophenyl)-3,7-dimethyl-8-[3-(propan-2-yloxy)benzyl]-2-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide, 1,2-ETHANEDIOL, Beta-secretase 1, ... Authors: Vajdos, F.F, Varghese, A.H. Deposit date: 2012-06-15 Release date: 2012-10-03 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Spirocyclic sulfamides as beta-secretase 1 (BACE-1) inhibitors for the treatment of Alzheimer's disease: utilization of structure based drug design, WaterMap, and CNS penetration studies to identify centrally efficacious inhibitors. J.Med.Chem., 55, 2012
创建时间：
2012-06-15
