We herein document a large collection of 108 2-amino-4,6-disubstituted-pyrimidine derivatives as potent, structurally simple, and highly selective A1AR ligands. The most attractive ligands were confir
An unprecedented ligand-controlled regiodivergent Cu(I)-catalyzed asymmetric intermolecular (3 + 2) cycloaddition reaction of α-substituted iminoesters with β-fluoromethyl β,β-disubstituted enones wa
A new subpharmacophore-based virtual screening method is introduced. Subpharmacophores are derived from large active molecules to detect small bioactive molecules as seeds for starting points in medic
Activation of human toll-like receptor-8 (TLR8) evokes a distinct cytokine profile favoring the generation of Type 1 helper T cells. A multiplexed high-throughput screen had led to the identification
A surface plasmon resonance (SPR) assay is used to determine binding affinities of commercial compound analogues previously selected to explore the structure activity relationship (SAR) around our pri