Foodomics study on the anti-proliferative activity mechanisms on HT-29 colon cancer cells in response to banana passion fruit (Passiflora mollissima) seeds PLE-extract

Passiflora mollissima commonly known as “banana passion fruit” is usually consumed as fresh food or processed products, being seeds and peel the main by-products of the industrial processing. The potentially bioactive metabolites from banana passion fruit PLE-extract seeds have been recently characterized by HPLC-HRMS after sequential pressurized liquid extraction (PLE) To apply a Foodomics approach to study the effects of a banana passion fruit seeds PLE-extract (with high antioxidant capacity and enriched in phenolic-type compounds) on the transcriptome and metabolome of HT-29 colon cancer cells. Transcriptome and metabolome analyses of HT-29 colon cancer cells untreated or treated with a banana passion fruit seeds PLE-extract for 48 hours. Three biological replicates were included in the experiment.