Longevity-promoting genes are expressed lower in zfp-1(ok554) and rde-4(ne299).

Venn diagrams are used to show overlaps between the “Class 1” longevity-promoting gene set from [23], gene sets determined to be UP- or DOWN-regulated in the mutants according to [19] and direct ZFP-1 target genes identified by ChIP/chip (modENCODE). Gene sets were first mapped to 18,459 genes with TOPOMAP [73] representation (with recalls ranging from 74% to 84%), and TOPOMAP-represented genes were included in the Venn diagrams. Fisher's exact test was used for calculating p values for overlaps.