Joo et al., "The mitotic ATR-Chk1 pathway promotes CDK1 activity for faithful chromosome segregation."

NIAID Data Ecosystem2026-05-02 收录

细胞周期调控

染色体分离机制

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Uncropped immunofluorescence and raw western blot images that are shown in Joo et al., 2025 manuscript.

创建时间：

2025-06-25

A Transient Expression of Prospero Promotes Cell Cycle Exit of Drosophila Postembryonic Neurons through the Regulation of Dacapo

发育生物学

细胞周期调控

Cell proliferation, specification and terminal differentiation must be precisely coordinated during brain development to ensure the correct production of different neuronal populations. Most Drosophil

NIAID Data Ecosystem70

Arrest of G(1)-S Progression by the p53-Inducible Gene PC3 Is Rb Dependent and Relies on the Inhibition of Cyclin D1 Transcription

细胞周期调控

肿瘤抑制基因

The p53-inducible gene PC3 (TIS21, BTG2) is endowed with antiproliferative activity. Here we report that expression of PC3 in cycling cells induced accumulation of hypophosphorylated, growth-inhibitor

PubMed Central30

Cumulative Effect of Phosphorylation of pRB on Regulation of E2F Activity

细胞周期调控

磷酸化机制

The product of the retinoblastoma susceptibility gene, pRB, is a nuclear phosphoprotein that controls cell growth by binding to and suppressing the activities of transcription factors such as the E2F

PubMed Central20

A kinase-phosphatase switch transduces environmental information into a bacterial cell cycle circuit. Caulobacter vibrioides

细胞周期调控

环境胁迫信号转导

The bacterial cell cycle has been extensively studied under standard growth conditions. How it is modulated in response to environmental changes remains poorly understood. Here, we demonstrate that th

NIAID Data Ecosystem60

DataSheet4_PRR11 promotes cell proliferation by regulating PTTG1 through interacting with E2F1 transcription factor in pan-cancer.zip

癌症分子机制

细胞周期调控

The upregulated proline rich 11 (PRR11) plays a critical role in cancer progression. The relevant biological functions of PRR11 in pan-cancer development are not well understood. In the current study,

NIAID Data Ecosystem30

Joo et al., "The mitotic ATR-Chk1 pathway promotes CDK1 activity for faithful chromosome segregation."

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