Variants with an unknown significance or conflicting interpretation of clinical significance.

VUSs (N = 170) from the targeted regions of 85 genes with a tallied consensus score for 9 in silico prediction algorithms. The review status definition was provided by ClinVar as follows: (3) reviewed by expert panel, (2) two or more submitters with assertion criteria and evidence provided the same interpretation, or (1) multiple submitters provided assertion criteria and evidence but there are conflicting interpretations.
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