Crystal structure of the human TTK in complex with an inhibitor
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Crystal structure of the human TTK in complex with an inhibitor Descriptor: 1,2-ETHANEDIOL, 4-({5-chloro-4-[(cis-4-hydroxy-4-methylcyclohexyl)oxy]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)-N,N-dimethyl-3-{[(2R)-1,1,1-trifluoropropan-2-yl]oxy}benzamide, Dual specificity protein kinase TTK, ... Authors: Fenalti, G. Deposit date: 2018-11-26 Release date: 2019-05-15 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy. J.Med.Chem., 62, 2019
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2018-11-26
