Bidentate Ligands on Osmium(VI) Nitrido Complexes Control Intracellular Targeting and Cell Death Pathways
收藏NIAID Data Ecosystem2026-03-07 收录
下载链接：
https://figshare.com/articles/dataset/Bidentate_Ligands_on_Osmium_VI_Nitrido_Complexes_Control_Intracellular_Targeting_and_Cell_Death_Pathways/2373484
下载链接
链接失效反馈官方服务：
资源简介：
The
cellular response
evoked by antiproliferating osmium(VI) nitrido
compounds of general formula OsN(N^N)Cl3 (N^N = 2,2′-bipyridine 1, 1,10-phenanthroline 2, 3,4,7,8-tetramethyl-1,10-phenanthroline 3, or 4,7-diphenyl-1,10-phenanthroline 4) can
be tuned by subtle ligand modifications. Complex 2 induces
DNA damage, resulting in activation of the p53 pathway, cell cycle
arrest at the G2/M phase, and caspase-dependent apoptotic cell death.
In contrast, 4 evokes endoplasmic reticulum (ER) stress
leading to the upregulation of proteins of the unfolded protein response
pathway, increase in ER size, and p53-independent apoptotic cell death.
To the best of our knowledge, 4 is the first osmium compound
to induce ER stress in cancer cells.
创建时间：
2016-02-18
