Deubiquitination

This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>本事件系基于在其他物种中已验证的事件进行计算机推断得出。该推断基于PANTHER的同源映射。简言之，对于所有涉及物理实体（包括输入、输出和催化剂）均具有映射同源/旁系同源的反应（对于复合体而言，至少75%的组分必须具备映射），将其推断至其他物种。同时，对这些事件也进行了高级别事件的推断，以便利导航。有关Reactome中事件推断的更多细节及注意事项，请参阅<a href='/electronic_inference_compara.html' target = 'NEW'>此处</a>。欲了解PANTHER的详细信息，请参见<a href='http://www.pantherdb.org/about.jsp' target='NEW'>此链接</a>。

搜集汇总

背景与挑战

背景概述

去泛素化（Deubiquitination）是泛素化修饰的逆过程，由去泛素化酶（DUBs）催化，通过移除蛋白质上的泛素分子来调控蛋白质降解、信号转导等功能。该通路基于人类数据通过同源映射推断到非洲爪蟾，涵盖了DUBs的五个家族及其催化机制。