Since the ignition of the HIV-1 group M pandemic in the beginning of the 20th century, group M lineages have spread heterogeneously throughout the world. Subtype C spread rapidly through sub-Saharan A
aMeasurements of CHOP were performed in 10 mM phosphate buffer (pH 7.0, 25°C), in the presence of increasing concentrations of l-cysteine. Calculations were performed using CDNN [108].