Integrated Somatic and Germline Molecular Properties Dictating Biological and Clinical Phenotypes in Cancer

Study version 1: We performed single-nuclei matched RNA- and ATAC-sequencing of frozen biopsies from normal adjacent tissue, primary and metastatic esophageal adenocarcinoma specimens. The data was then further stratified into a tumor microenvironment and malignant compartment and was computationally analyzed to reveal cancer cell subtypes and programs driving malignancy.Study version 2: We performed single nucleus multiome sequencing (simultaneous ATAC and RNA sequencing) on snap frozen adipose and liposarcoma patient samples.