One-step generation of modular CAR-T with AAV-Cpf1
收藏NIAID Data Ecosystem2026-03-10 收录
下载链接：
https://www.ncbi.nlm.nih.gov/bioproject/PRJNA509600
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资源简介：
Chimeric antigen receptor (CAR) T cells have become powerful players in immune-based cancer therapy space, but current lentiviral and retroviral-based production systems are limited by cost and modularity. Improved systems for efficient generation and enhanced features are therefore of great interest. Here we developed a method using the CRISPR-Cpf1 system to generate a stable CAR-T based on homology-directed repair (HDR) knock-in and immune checkpoint knockout in one step.
创建时间：
2018-12-12
