MicroRNA (miRNA) Expression in Circulating Leukocytes and Bioinformatic Analysis of Patients with Moyamoya Disease (MMD)

To investigate the differential expression of miRNAs in circulating leukocytes of patients with MMD. The results showed 12 differentially expressed miRNAs in leukocytes of MMD patients compared with controls (fold change > 2.0 and P < 0.05), of which 7 were up-regulated and 5 were down-regulated. A total of 30 MMD patients and 10 healthy adults were enrolled. The gene microarray was used to detect the differential expression profiles of miRNAs in leukocytes between patients with moyamoya disease and healthy controls.