Transcriptomic profiling of MDA-MB-231 cells treated with cytostatic compounds. Transcriptomic profiling of MDA-MB-231 cells treated with cytostatic compounds

Transcriptomic profiling of MDA-MB-231 cells treated with Paclitaxel , 4-ethyl-N-(7-hydroxy-3,4-dihydroisoquinolin-2-(1H)-yl)benzamide (GM-453) or LDHAB inhibitor (6R)-3-[(2-Chlorophenyl)thio]-5,6-dihydro-4-hydroxy-6-[4-(4-morpholinyl)phenyl]-6-(3-thienyl)-2(1H)-pyridinone, (R)-3-(2-Chlorophenyl)sulfanyl-6-(4-morpholinophenyl)-6-(3-thienyl)piperidine-2,4-dione (GNE-140) Overall design: The effects of cytostatic compounds paclitaxel , 4-ethyl-N-(7-hydroxy-3,4-dihydroisoquinolin-2-(1H)-yl)benzamide (GM-453) and GNE-140 (an LDHAB inhibitor) were evaluated for effects on the whole transcriptome: including mRNAs and long intergenic non-coding RNA transcripts using GeneChip™ Human Gene 2.1 ST Arrays by Affymetrix Inc.