Slc6a3

Enables dopamine binding activity; dopamine:sodium symporter activity; and neurotransmitter transmembrane transporter activity. Involved in dopamine uptake; hyaloid vascular plexus regression; and neurotransmitter uptake. Acts upstream of or within several processes, including dopamine metabolic process; lactation; and prepulse inhibition. Located in axon terminus and cell surface. Is expressed in genitourinary system; nervous system; spleen; and submandibular gland. Used to study Gilles de la Tourette syndrome; attention deficit hyperactivity disorder; and schizophrenia. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; classic dopamine transporter deficiency syndrome; mild cognitive impairment; nicotine dependence; and obesity. Orthologous to human SLC6A3 (solute carrier family 6 member 3). [provided by Alliance of Genome Resources, Nov 2024]

该数据集包含多巴胺结合活性、多巴胺-钠离子转运蛋白活性和神经递质跨膜转运蛋白活性。参与多巴胺摄取、玻璃体血管丛退化以及神经递质摄取过程。在多巴胺代谢过程、泌乳和预脉冲抑制等若干上游或内部过程中发挥作用。位于轴突末端和细胞表面。在泌尿生殖系统、神经系统、脾脏和下颌下腺中表达。用于研究妥瑞综合症、注意力缺陷多动障碍和分裂症。与注意力缺陷多动障碍、经典多巴胺转运蛋白缺乏综合征、轻度认知障碍、尼古丁依赖和肥胖症相关的人类基因同源物。与人类SLC6A3（溶质载体家族6成员3）同源。[由基因组资源联盟提供，2024年11月]