Design of a gene signature to analyze the proinflammatory and the profibrotic polarization of murine fibroblasts and validation in an experimental murine model of scleroderma.

Effect of TGFb1, TNFa, IL6-IL6R, IL1b on gene expression in Mouse Embryonnic Fibrobroblasts (3T3) using RNA microarrays. Enrichment analysis of the differentially expressed genes (DEGs) regulated by TGFb1, TNFa, IL6-IL6R, or IL1 compared to control in Mouse Embryonnic Fibroblasts (3T3).