Compromised femoral and lumbovertebral bone in the Dp(16)1Yey Down syndrome mouse model

Down syndrome (DS), affecting ~1 in 800 live births, is caused by the triplication of human chromosome 21 (Hsa21). Individuals with DS have skeletal features including craniofacial abnormalities and decreased bone mineral density (BMD). Lowered BMD can lead to increased fracture risk, with common fracture points at the femoral neck and lumbar spine. While the femur has been studied in DS mouse models, there is little research done on the vertebrae despite evidence that humans with DS have affected vertebrae. Additionally, it is important to establish when skeletal deficits occur to find times of potential intervention. The Dp(16)1Yey DS mouse model has all genes triplicated on mouse chromosome 16 orthologous to Hsa21 and displayed deficits in long bone, including trabecular and cortical deficits in male but not female mice, at 12 weeks. We hypothesized that the long bone and lumbovertebral microarchitecture would exhibit deficits in Dp(16)1Yey mice compared to control mice, long bone st..., , , # Data from: Compromised femoral and lumbovertebral bone in the Dp(16)1Yey Down syndrome mouse model

The following data was utilized in the following manuscript: (citation information)

Femoral length and mechanical parameters could not be completed for Yey58 and Yey66 due to being broken after uCT scanning. Trabecular parameters (BMD, BV/TV, Tb.Th, Tb.Sp, Tb.N) were reported for right femurs (Fem.)and 4th lumbar vertebra (Vert.) Cortical parameters (Tt.Ar, Ma.Ar, Ct.Ar, Ct.Ar/Tt.Ar, Ct.Th, Ps.Pm, Ec.Pm, Ct.TMD) were reported for right femurs. Mechanical parameters (remaining) were reported based on 3-point bend for right femurs. Three femurs (Yey55,Yey68,Yey77) did not reach a failure point (break), so failure points may be overestimated (they are reported for creation of the Force-Displacement and Stress-Strain curves).

Columns are as follows:
Sample ID
Age of animal at dissection in weeks
Sex where M = male and F = female
Genotype
Body weight (Bod.Weight) in grams
Femoral length (F...