Results of cross platform validation of the schizophrenia vs control comparison for endothelial cells.

Based on the Affymetrix data, the 200 genes whose expression was most upregulated in schizophrenia (AFFY_UP), and the 200 genes whose expression was the most downregulated in schizophrenia (AFFY_DOWN) were used to create categories for analysis in the ranked list (schizophrenia vs control) derived from the Codelink platform. A positive enrichment score indicates enrichment in schizophrenia samples, and a negative enrichment score indicates enrichment in control samples. These were all found to be significantly enriched in the expected direction in the Codelink data (q<0.25). The converse procedure was carried out testing categories generated from the Codelink data (CL_UP, CL_DOWN) on the Affymetrix platform, with comparable results.