Persistent mTORC1 activation due to loss of liver tuberous sclerosis complex 1 promotes liver injury in alcoholic hepatitis.

The aim of the study is to investigate the role and mechanisms of tuberous sclerosis complex 1 (TSC1) and mechanistic target of rapamycin complex 1 (mTORC1) in alcohol associated liver disease Hepatic RNA profiles of WT and hepatic TSC1 KO mice fed with alcohol or control diet using Gao binge alcohol model. Comparative gene expression profiling analysis of RNA-seq data for TSC1 WT and hepatic TSC1 KO mouse livers.本研究旨在探讨结节性硬化症复合体1（TSC1）与雷帕霉素机制性靶标复合体1（mTORC1）在酒精相关性肝病中的作用及分子机制。本数据集依托Gao酗酒模型，采集了喂食酒精或对照饲料的野生型（Wild Type, WT）小鼠及肝脏特异性TSC1敲除（Knock Out, KO）小鼠的肝脏转录组信息，并针对TSC1野生型与肝脏特异性TSC1敲除小鼠的肝脏组织RNA测序（RNA-seq）数据开展比较基因表达谱分析。