Adverse Outcome Pathway on impaired interleukin‑1 receptor type I (IL‑1R1) signaling leading to impaired T‑cell dependent antibody response

Stressors that exhibit immunosuppression might act by different mechanisms, i.e. alter the number of cells involved in the immune response, the ability of the cells to produce cytokines, chemokines, antibodies or growth factors, the composition of the subpopulations of cells present at the site of the response, or the function of the cells. This...