Comparison of expression profiles of SCD::Keap1F/F and SCD::Keap1F/F::Tie1-Cre mouse pulmonary primary endothelial cells(MPPCECs)

This experiment evaluate the expression level of Nrf2 genes transcript in mouse primary endothelial cells of a pathology model mice of Sickle cell disease (SCD). Constitutive activation of Nrf2 in SCD suppresses inflammation and organ injury. In the present study we aim to assess the benefit of specific- cell Nrf2 activation in endothelial ceels exclusively. mRNA profiles of SCD::Keap1F/F and SCD::Keap1F/F::Tie1-Cre of MPPCECs were generated by deep sequencing, in triplicate.