the transcriptome sequencing on samples from different stages of Atherosclerosis

The differential expression profiles of mRNAs and ncRNAs during different stages of atherosclerosis have not yet been reported. We carried out whole-transcriptome sequencing and identified the expression profiles of mRNAs and essential ncRNAs (circRNAs and lncRNAs) in three groups of mice with varying degrees of atherosclerosis. 8-week-old ApoE-/- mice were administrated an HFD for different durations to model different stages of AS in the present study. The mice receiving an HFD for 0, 4 and 16 weeks from 8 weeks of age were considered the normal (NO), early AS (EA) and advanced AS (AD) groups, respectively. The data may provide a new research direction for future in-depth studies.