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HtrA, fatty acid-lipid composition, and membrane proteins interplay in Chlamydia trachomatis to impact on cellular exit

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NIAID Data Ecosystem2026-05-01 收录
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Chlamydia trachomatis serovar D plaque purified strains were passaged in the presence of the HtrA inhibitor compound JO146 to select for resistant mutants. 3 strains that were least susceptible to JO146 were selected for whole genome sequencing. 2 of the 3 strains were mutated using ethyl methanesulfonate (EMS) prior to passaging in the presence of JO146.

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2024-02-20
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