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IRF-5 and IRF-8 govern the response of Human Plasmacytoid Dendritic Cells following TLR9 ligation

ChEBI2016-06-01 更新2026-07-12 收录

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树突状细胞免疫调控

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-70429 数据链接链接失效反馈

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资源简介：

IRF-5 and IRF-8 govern the response of Human Plasmacytoid Dendritic Cells following TLR9 ligation

应用场景：

创建时间：

2016-06-01

树突状细胞免疫调控

转录因子功能

Interferon regulatory factor-8 (IRF8) has been proposed to be essential for development of monocytes, plasmacytoid dendritic cells (pDCs) and type 1 conventional dendritic cells (cDC1s) and remains hi

NIAID Data Ecosystem90

Mechanisms Establishing TLR4-Responsive Activation States of Inflammatory Response Genes

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炎症与表观遗传调控

Precise control of the innate immune response is required for resistance to microbial infections and maintenance of normal tissue homeostasis. Because this response involves coordinate regulation of h

NIAID Data Ecosystem60

Inherited human IRAK-1 deficiency selectively abolishes TLR signaling in fibroblasts

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免疫表型

We describe here a male infant with a 100 kb de novo Xq28 deletion encompassing parts of the TMEM187 and MECP2 protein-coding genes and the IRAK1 protein-coding gene, as well as the MIR3202-1, MIR3202

NIAID Data Ecosystem50

PIKfyve controls dendritic cell function and tumor immunity I. PIKfyve controls dendritic cell function and tumor immunity I

树突状细胞免疫调控

免疫治疗机制

To understand the mechanism of Pikfyve loss in dendritic cells, we cultured conventional dendritic cells isolated from the bone marrow of Pikfyvef/f (“WT”) and mice with ItgaxTg/0 Pikfyvef/f (“KO”) mi

NIAID Data Ecosystem70

Gp130-dependent release of acute phase proteins is linked to the activation of innate immune signaling pathways

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细胞基因调控

Gp130 dependent gene expression was analyzed in a previously established hepatocyte-specific gp130-knockout mouse model. Whole transcriptome analysis for isolated hepatocytes was performed to measure

NIAID Data Ecosystem50

IRF-5 and IRF-8 govern the response of Human Plasmacytoid Dendritic Cells following TLR9 ligation

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