Pan-Cancer Single Cell Landscape of Tumor-Infiltrating T Cells

T cells present diverse states in the tumor, playing a central role in cancer immunity and immunotherapies. However, their heterogeneity, dynamics and composition within tumors of various cancer types are not fully characterized. Integrating a pan-cancer single-cell RNA sequencing atlas of T cells cross multiple cancer types, we systematically characterized their diversity, identified the potentially tumor-reactive T cells, and revealed new cell types. Our findings provide new insights into T cell immunity and will facilitate immunotherapy development targeting T cells in human cancer. We generated scRNA-seq data from cancer patients to investigate tumor-infiltrating T cells across multiple cancer types. Please note that processed data files generated from multiple samples are available on Series record and are indicated in the associated sample description field. ****Raw sequence data were provided at China Genomic Sequence Archive (GSA). The accession number will be included once the paper is accepted.