Cediranib/SC68896 treatment increases tumor necrosis.

A) Representative H&E stained sections from the four treatment groups, indicating areas of necrosis, which appear as loss of nuclear staining in areas of vacuolated tissue (see arrow). B) Percent necrosis, quantified from multiple H&E stained sections, for the four treatment groups. Significantly greater necrosis was observed for the cediranib/SC68896 versus untreated (pC) Viable tissue sections stained for caspase-3, a marker of apoptosis, are shown for the different treatment groups. Arrow indicates caspase-3 positive cell examples. D) The mean number of caspase-3 positive cells/10X field in viable tissue is shown. No significant differences were observed among the treatment groups.