Studies on the water-promoted synthesis of chalcones. A contribution to the green synthesis of organic compounds

Supporting information. Herein, a methodology for the water-promoted synthesis of chalcones is presented, a green methodology, that pretends adding to the new ecologic tendencies and showing the capabilities and limitations of water to promoting the synthesis of organic molecules. Reaction proceeds at room temperature using only KOH (a green base and shown a broad applicability, since 38 derivatives were prepared in good to excellent yields (up to 98%). In addition, most compounds were recovered pure enough by simply filtration and water washing.

本部分提供了支持信息。在此，提出了一种水助合成的查尔酮的方法，该方法是一种绿色化学方法，旨在响应新的生态趋势，并展示了水在促进有机分子合成中的潜力和局限性。反应在室温下进行，仅使用氢氧化钾（一种绿色碱，具有广泛的应用性，自38种衍生物以良好的至优秀的产率（高达98%）被制备以来）作为催化剂。此外，大多数化合物通过简单的过滤和水洗即可纯化至足够高的纯度。