Synthesis of β-Fluoroamines by Lewis Base Catalyzed Hydrofluorination of Aziridines
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https://figshare.com/articles/dataset/Synthesis_of_Fluoroamines_by_Lewis_Base_Catalyzed_Hydrofluorination_of_Aziridines/2529352
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Lewis base catalysis promotes the in situ generation of amine-HF reagents from benzoyl fluoride and a non-nucleophilic alcohol. The hydrofluorination of aziridines to provide β-fluoroamines using this latent HF source is described. This protocol displays a broad scope with respect to aziridine substitution and N-protecting groups. Examples of regio- and diastereoselective ring opening to access medicinally relevant β-fluoroamine building blocks are presented.
创建时间：
2016-02-21
