Associations of rate of atrophy with changes in plasma biochemical markers upon treatment^a.

Abbreviations: HoloTC, holotranscobalamin; TC saturation, ratio of holoTC to total TC; tHcy, plasma total homocysteine. aActive treatment group received daily supplements of folic acid (0.8 mg), vitamin B12 (0.5 mg) and vitamin B6 (20 mg) for 24 months. bAll subjects in the MRI subgroup that started treatment and with baseline and follow-up blood sampling. cThe actively treated subjects where classed as compliant if they had an increase from baseline to follow-up in plasma folate of >10 nmol/L and in vitamin B12 of >150 pmol/L; the placebo subjects were classed as compliant if the increase from baseline to follow-up was ≤10 nmol/L in plasma folate and ≤150 pmol/L in plasma vitamin B12. dAdjusted for age, baseline diastolic blood pressure, baseline creatinine, initial brain volume and log baseline tHcy.